M. Schaefer et al. reported on the first experience with the novel agent LiftUp for submucosal injection. 10 consecutive patients (median age 74.5 years; 6 male, 4 female) with colorectal polyps ≥ 15 mm were included. Lesions were localized in the rectum (n=5), caecum (n=2), sigmoid (n=1), transverse colon (n=1), and ascending colon (n=1) and the median lesion size was 20.5 mm (range: 15-30 mm). To assess endoscopic resection after LiftUp injection, EMR (8 patients) or ESD (2 patients) were performed. Median volume of LiftUp was 5.25 ml (range 2-12 ml) and median procedure time was 2.25 minutes for EMR and 5.5 minutes for ESD. In all 10 cases macroscopic complete resection was achieved and the R0 resection rate was 78 % (7/9). No adverse events occurred.

The authors concluded that endoscopic resection with LiftUp is feasible, safe, and fast. However, larger studies are needed for better evaluation of efficacy and safety.