Insilico Biotechnology AG has successfully concluded another step in the further development of its existing technology platform for simulating biochemical processes in living cells. A model of the liver including blood flow is now available. The platform offers benefits in particular to customers from the pharmaceutical, chemical and cosmetics industries, who can use this technology to perform computer-based toxicity tests.
The liver is a key organ in the body and is responsible for breaking down and excreting metabolites, drugs and toxins. Stuttgart-based Insilico Biotechnology AG has been researching these complex processes over a number of years and as a system biotechnology expert has developed a platform that maps these processes in silico, i.e. on a computer. After initiating a virtual liver cell for drug development in 2007, the company has now created a spatial model of the liver including blood flow. The new model is able to process data at cellular and organ level. In the medium term, Insilico Biotechnology plans for the platform to be used as a modular system that can be expanded with other organs such as the heart and kidneys. Ultimately, this will produce a whole-body model on which all the characteristics and reactions of an individual organism can be simulated and tested. As well as characteristics such as sex, age and weight, the virtual liver can already map genome-based breakdown pathways for toxic substances, thereby enabling the generation of reliable information on time and dose-related effects among various groups of patients.
The platform, which is embedded into the company’s high-performance IT structure, can be used in various locations and is highly efficient. For example, information on metabolic changes as a result of administering specific substances is available within a few minutes instead of one to two days, as was previously the case.
The platform technology can be deployed by the chemical, pharmaceutical and cosmetics industries to carry out toxicological tests. The model will therefore enable a cut in animal testing over the long term. This is also important in the context of the new EU chemical regulation REACH on registering, evaluating and authorising chemicals which stipulates that manufacturers and importers must examine the effects of chemicals on human health.
The company has grown rapidly since it was founded in 2001 and recently relocated to larger premises. Around 20 employees work on simulating biochemical processes in living cells at the site in the STERN BioRegion. “We are glad to be successful in solving technically demanding problems,” says CEO Klaus Mauch. “But we’re particularly proud that our solutions are being implemented commercially in collaboration with leading industrial partners.”