06/01/2023 | CeGaT GmbH | News

CeGaT and Twist Bioscience Launch RNA Fusion Panel to Advance Oncology and Precision Medicine Research

RNA fusions can be used as biomarkers to identify cancer sub-types and monitor for residual disease

Tübingen, June 01, 2023:–  CeGaT GmbH, a global provider of sequencing services for research, clinical studies, and human genetic diagnostics, and Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, today announced the launch of the Twist Alliance CeGaT RNA Fusion Panel, which is designed to detect RNA fusions and conduct transcript variant analysis for oncology research. RNA fusions are the result of parts from two different genes fusing together. This can happen during chromosomal arrangements, which frequently occur in cancers.

“RNA fusions often go undetected by PCR sequencing methods if one of the gene parts is unknown and by whole transcriptome analysis, especially when the sample input is degraded,” said Dirk Biskup, Ph.D., managing director and co-founder of CeGaT. “We combined Twist’s RNA Library Prep and target enrichment capabilities with our expert knowledge in tumor diagnostics and panel design. This is how together we created the Twist Alliance CeGaT RNA Fusion Panel enriching for over one hundred and fifty fusion genes. This panel is designed to deliver high-quality results, even from low-input samples.”

RNA fusions are known drivers of disease evolution and progression, making them key biomarkers for oncology studies. Detection of fusion events can be used by researchers to identify molecular subtypes of cancers, which could inform studies concerning precision treatment options. They can also be used by researchers to monitor for minimal residual disease (MRD) following treatment.

“As we expand into the RNA market, the Twist Alliance CeGaT RNA Fusion Panel adds to our growing RNA sequencing toolset, which includes the Twist RNA Exome, RNA Library Prep and rRNA and Globin Depletion Kit. It also adds to our growing portfolio of DNA and RNA products that could be used to support precision medicine research in oncology,” said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. “By partnering with CeGaT, we are able to offer researchers an end-to-end library prep workflow with Twist RNA Library Prep and fusion capture and CeGaT’s software analysis.”

About Twist Alliance CeGaT RNA Fusion Panel

The Twist Alliance CeGaT RNA Fusion Panel utilizes Twist RNA Library Prep and fusion capture along with CeGaT’s software analysis to detect fusions in specific tumor types and identify novel fusion events. The panel includes over one hundred and fifty fusion genes.

About CeGaT

CeGaT is a global provider of genetic analyses for a wide range of medical, research, and pharmaceutical applications.

Founded in 2009 in Tübingen, Germany, the company combines state-of-the-art sequencing technology with medical expertise – with the aim of identifying the genetic causes of diseases and supporting patient care. For researchers and pharmaceutical companies, CeGaT offers a broad portfolio of sequencing services and tumor analyses. CeGaT generates the data basis for clinical studies and medical innovations and drives science forward with its own insights.

The owner-managed company stands for independence, comprehensive personal customer service, and outstanding quality. CeGaT’s laboratory is accredited according to CAP/CLIA, DIN EN ISO 15189, and DIN EN ISO 17025 and thus meets the highest international standards. To obtain first-class results, all processes are carried out in-house under scientific supervision.

About Twist Bioscience Corporation

Twist Bioscience is a leading and rapidly growing synthetic biology and genomics company that has developed a disruptive DNA synthesis platform to industrialize the engineering of biology. The core of the platform is a proprietary technology that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Twist is leveraging its unique technology to manufacture a broad range of synthetic DNA-based products, including synthetic genes, tools for next-generation sequencing (NGS) preparation, and antibody libraries for drug discovery and development. Twist is also pursuing longer-term opportunities in digital data storage in DNA and biologics drug discovery. Twist makes products for use across many industries including healthcare, industrial chemicals, agriculture and academic research.

Further information

CeGaT contact:

Nora Zeller
07071 565 44 260
nora.zeller@cegat.de

Source:
https://cegat.com/cegat-and-twist-bioscience-launch-rna-fusion-panel-to-advance-oncology-and-precision-medicine-research/