The "Pharmacoomics and Breast Cancer group" is looking for a candidate to work on the topic “Luminal-to-basal tumor heterogeneity of hormone-receptor positive breast cancer”. The PhD project will address various aspects of tumor cell biology including tumor heterogeneity, molecular characterizations, and clinical aspects of cancer research.

Job Description

• Application of a broad spectrum of basic molecular and cell biological techniques, including absorbance/luminescence measurements, immunohistochemistry, and immunofluorescence microscopy
• Biomarker analyses on tumor tissue sections using QuPath Software
• Characterization of primary tumors on different molecular levels using state-of-the-art methods: genomics (digital droplet PCR, MassARRAY, NGS), spatial transcriptomics, spatial phenotyping
• Establishment and characterization of patient-derived tumor models (e.g., organoids)
• Functional testing of drug effects using in vitro and pre-clinically relevant in vivo models
• Analysis of clinical and experimental datasets (e.g., immunohistochemistry, gene expression, genetic variation) using biostatistics and bioinformatics

Qualifications

• Master degree (M.Sc.) in biology, biochemistry, molecular medicine, or a related discipline
• Experience and solid background in molecular biology, human genetics and cell culture technology
• Preliminary experience with 3D cell/tumor model culture, or tissue molecular pathology is beneficial
• Interest in oncology and personalized medicine
• Excellent English written and oral communication skills
• Enthusiasm to dedicate yourself to ensure greatest possible success in your career track

Additional Information

We offer:

• The opportunity to work in an interdisciplinary team providing support and mentoring at IKP and University of Tübingen
• State-of-the-art technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities
• The opportunity to communicate scientific results at international conferences and to participate in workshops/seminars
• A unique feature of the project is the co-supervision by a team of renowned investigators from the Moross Integrated Cancer Center at Weizmann Institute of Science, Israel , who contribute with their unique expertise to the progress of the projects
• An initial contract for 3 years and flexible starting date (earliest starting date as of now)