PhD Student (m/f/d)

The Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart (Director Prof. Dr. M. Schwab) is operated by the Robert Bosch Foundation. Since its foundation in 1973, the institute has emerged as Germany's largest and most renowned research unit in the field of clinical pharmacology. Main research activities concentrate on the influence of genetic and non-genetic factors on the variability of drug efficacy and their contributions to disease development.

The "Pharmacoomics and Breast Cancer group" is looking for a candidate to work on the topic Luminal-to-basal tumor heterogeneity of hormone-receptor positive breast cancer”. The PhD project will address various aspects of tumor cell biology including tumor heterogeneity, molecular characterizations, and clinical aspects of cancer research.

Job Description

  • Application of a broad spectrum of basic molecular and cell biological techniques, including absorbance/luminescence measurements, immunohistochemistry, and immunofluorescence microscopy
  • Biomarker analyses on tumor tissue sections using QuPath Software
  • Characterization of primary tumors on different molecular levels using state-of-the-art methods: genomics (digital droplet PCR, MassARRAY, NGS), spatial transcriptomics, spatial phenotyping
  • Establishment and characterization of patient-derived tumor models (e.g., organoids)
  • Functional testing of drug effects using in vitro and pre-clinically relevant in vivo models
  • Analysis of clinical and experimental datasets (e.g., immunohistochemistry, gene expression, genetic variation) using biostatistics and bioinformatics


  • Master degree (M.Sc.) in biology, biochemistry, molecular medicine, or a related discipline
  • Experience and solid background in molecular biology, human genetics and cell culture technology
  • Preliminary experience with 3D cell/tumor model culture, or tissue molecular pathology is beneficial
  • Interest in oncology and personalized medicine
  • Excellent English written and oral communication skills
  • Enthusiasm to dedicate yourself to ensure greatest possible success in your career track

Additional Information

We offer:

  • The opportunity to work in an interdisciplinary team providing support and mentoring at IKP and University of Tübingen
  • State-of-the-art technologies for a wide range of different applications (genomics, transcriptomics, metabolomics) and expert knowledge within the different core facilities
  • The opportunity to communicate scientific results at international conferences and to participate in workshops/seminars
  • A unique feature of the project is the co-supervision by a team of renowned investigators from the Moross Integrated Cancer Center at Weizmann Institute of Science, Israel , who contribute with their unique expertise to the progress of the projects
  • An initial contract for 3 years and flexible starting date (earliest starting date as of now)

For further information please contact Dr. Werner Schroth (phone 0711-8101-5647, email:

Are you ready for a new challenge? Then apply now via our online career portal.

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