The Cluster of Excellence EXC2180 “Image-Guided and Functionally Instructed Tumor Therapies (iFIT)” is a multidisciplinary and interdisciplinary research program that focuses on understanding tumor biology and the development of novel diagnostic and therapeutic approaches for cancer. The iFIT research group of Dr. Judith Feucht offers a position for a
Postdoctoral Fellow (f/m/d) in T cell engineering/ cancer immunotherapy.
The earliest possible start date is December 2020 and the position is offered for 1 year with plans for a further extension.
The laboratory of Dr. Judith Feucht aims at enhancing and extending immunotherapeutic approaches with Chimeric Antigen Receptors (CARs) - synthetic receptors that reprogram immune cells for therapeutic purposes. CAR T cells targeting CD19 are an effective treatment strategy in patients with refractory B cell malignancies. Despite the clinical success with induction of complete remissions at high frequencies, treatment with currently approved CAR designs is curative only in a fraction of patients. We will use highly innovative gene editing strategies and clinically relevant mouse models of solid tumors and metastatic disease to gain improved understanding into CAR biology and underlying mechanisms of therapeutic failures. We aim to translate our insights into enhanced CAR designs and improved therapies tailored to specific disease and treatment settings. The overall goal is to develop novel CAR designs, to identify synergistic treatment strategies and to extend CAR therapy to a broader range of disease.
- Planning and conducting research experiments; establishment of novel assays and models
- Analysis, interpretation and presentation of research findings
- Contribution to grant writing, research reports and publications
- Scientific literature research and development of new ideas
- Development of both internal and external collaborations
- Supervision of master and PhD students
- A doctoral degree in biosciences (PhD, MD or equivalent)
- Ability to independently solve complex scientific/ technical questions
- Practical experience in cell culture techniques, immunological assays and/or molecular biological methods
- Excellent organization, communication and documentation skills
- Excellent proficiency (oral and written) in English
- Strong interest in the intersection of T cell engineering, immunology and clinical translation; high level of commitment and self-motivation
- Collegiality and ability to work in an interdisciplinary team
- Creativity and thinking outside the box are encouraged
- Practical skills in animal experimentation (FELASA B or comparable) are desirable
We offer an interesting and versatile workplace, a pleasant working atmosphere and an exciting project in a highly innovative and relevant research field. Salary is paid according to TV-L (collective wage agreement for the Public Service of the German Federal States) in addition to all the customary benefits granted to employees working in Public Services. Severely handicapped persons with equal qualifications are given preferential consideration. The University of Tübingen is committed to increase
the percentage of female scientists and therefore encourages women to apply for this position. The Administration of the University Hospital is responsible for all employment matters. Personnel appointments will be made pursuant to the fundamental stipulations of the legal statutes for universities in Germany. Interview expenses are not covered.
Please send your application including a brief cover letter, your CV, a publication list as well as contact details for two references via e-mail or in written form until 11/15/2020 to:
Dr. med. Judith Feucht
Cluster of Excellence EXC2180 "iFIT"